The Friday, July 4 MLB schedule is loaded with 15 games and several rivalry series getting underway. All 30 MLB teams scheduled to play on the national holiday. One of the most notable MLB matchups today is Dodgers vs. Astros at 9:10 p.m. ET in an inter-league matchup between two of the top World Series contenders in MLB. Los Angeles is listed as a -181 favorite (risk $181 to win $100) on the money line in the latest Astros vs. Dodgers odds. The SportsLine Projection Model is predicting a solid performance from Dodgers shortstop Mookie Betts, with the eight-time MLB All-Star projected to Over 0.5 total RBI at +159 odds (risk $100 to win $159).
The model is also calling for the Colorado Rockies to keep things closer than expected when they host the Chicago White Sox at Coors Field at 8:10 p.m. ET. SportsLine’s model is projecting a final score of 5.0-4.8 in Chicago’s favor in this game and is backing the Rockies (+1.5) on the run line at -147 odds (risk $147 to win $100). Before making any other MLB picks or building any MLB parlay cards, you’ll want to see the MLB predictions and betting advice from SportsLine’s proven computer simulation model. You can also check out our MLB prop picks and MLB home run picks for Friday.
The SportsLine Projection Model simulates every MLB game 10,000 times. It enters Week 15 of the 2025 MLB season on a profitable 39-30 run on top-rated MLB sides picks. It has excelled making home run prop picks this season, returning more than 24 units of profit. Anybody following at sportsbooks and on betting apps could have seen strong returns.
The model has broken down the MLB odds for Friday and just revealed its top picks and MLB player props. Combining the model’s four picks into an MLB parlay would result in a payout of +1896 (risk $100 to win $1,896). New users can even take advantage of the DraftKings promo code offering $150 in bonus bets instantly with a $5 wager.
Here are its best bets for the MLB slate on Friday.
- Anthony Senzatela Under 3.5 total earned runs allowed (-122)
- Eugenio Suarez Over 0.5 total RBI (+152)
- Mookie Betts Over 0.5 RBI (+159)
- Colorado Rockies (+1.5) on the run line vs. Chicago White Sox (-147)
- Combine these picks for a shot at a +1896 payout (odds subject to change)
Anthony Senzatela Under 3.5 total earned runs allowed (-122)
Senzatela and the Rockies host the Chicago White Sox on Friday, in what projects to be a solid matchup for the veteran right-hander. Senzatela has been one of the most productive pitchers in Rockies’ franchise history during his nine seasons in Colorado. SportsLine gives this pick an edge of 0.7 based on the projection of 2.8 earned runs allowed for Senzatela and the consensus line of 3.5.
Eugenio Suarez Over 0.5 total RBI (+152)
Suarez and the Diamondbacks host the Kansas City Royals on July 4 in a late night game starting at 9:40 p.m. ET. The 33-year-old veteran is in the midst of another highly productive season, and enters Friday batting .250 with 27 home runs and 70 RBI. SportsLine give this pick an edge of 0.3 based on the projection of 0.8 RBI for Suarez and the consensus line of 0.5.
Mookie Betts Over 0.5 RBI (+159)
Betts and the Dodgers host the Houston Astros on Friday at 9:10 p.m. ET in a game that could be a potential World Series preview. Betts enters Friday batting .246 with 10 home runs and 43 RBI. SportsLine gives this pick an edge of 0.3 based on the projection of 0.8 RBI for Betts and the consensus line of 0.5.
Colorado Rockies (+1.5) on the run line vs. Chicago White Sox
The Rockies are set to host the White Sox in a weekend series between the teams with the worst two records in MLB this season. The White Sox were swept by the Los Angeles Dodgers in their mid-week series leading up to this game, while the Rockies are coming off a 7-6 win over the Houston Astros on Thursday. The SportsLine Projection Model is predicting a final score of 5.0-4.8 in Chicago’s favor, with the Rockies covering on the run line in 68% of computer simulations.
Want more MLB picks for today?
You’ve seen some of the model’s MLB best bets for Friday. Now, get run line, total and money-line picks for every game here, all from the model that’s simulated every game 10,000 times.
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You can also see today’s top MLB picks from expert Matt Severance, who’s on a sizzling 173-103 roll on his last 276 MLB picks. Visit SportsLine to see his best plays for today, all from the expert who’s up more than 11 units.