Orioles vs. Guardians prediction, odds, start time: 2025 MLB picks, best bets for July 24 by proven model

The Cleveland Guardians will look for the four-game series sweep when they take on the Baltimore Orioles in a key American League matchup on Thursday afternoon. Cleveland is coming off a 3-2 win on Wednesday. The Orioles (44-57), who are fifth in the AL East, are 22-32 on the road this season. The Guardians (51-50), who are second in the AL Central, are 25-24 on their home field in 2025.

First pitch from Progressive Field in Cleveland is set for 1:10 p.m. ET. The Guardians have won five of the last seven meetings with the Orioles in games played in Cleveland, including three in a row. Cleveland is a -115 favorite on the money line (risk $115 to win $100) in the latest Orioles vs. Guardians odds from DraftKings Sportsbook, while the over/under for total runs scored is 9. Before making any Guardians vs. Orioles picks, be sure to see the MLB predictions and betting advice from SportsLine’s proven computer model.

The SportsLine Projection Model simulates every MLB game 10,000 times. It entered Week 17 of the 2025 MLB season 46-43 on top-rated MLB picks. It has excelled in making home run prop picks this season, returning more than 40 units of profit. Anybody following at sportsbooks and on betting apps could have seen strong returns.    

Now, the model has set its sights on Orioles vs. Guardians and just locked in its picks and MLB betting predictions. You can head to SportsLine now to see the model’s picks. Here are several MLB odds and betting lines for Orioles vs. Guardians, which you can get in on with a DraftKings promo code or a FanDuel promo code.

Why the Guardians can win

Left-hander Logan Allen (6-8, 4.06 ERA) is expected to get the start for Cleveland. He is expected to make his 20th appearance of the season, including his 19th start. In 95.1 innings pitched, he has allowed 93 hits, 43 earned runs and 39 walks with 74 strikeouts. He is coming off an 8-2 loss to the Athletics on Saturday. In 5.1 innings, he allowed eight hits, three earned runs and one walk, while striking out four.

Left fielder Steven Kwan is among Cleveland’s top hitters. In 95 games, he is batting .285 with 20 doubles, one triple, six homers, 33 RBI and 11 stolen bases. He was 2-for-3 with three walks and one run scored in Monday’s 10-5 win over the Orioles. He was 1-for-4 with two RBI in a 6-2 win over the Chicago White Sox on July 12. See which team to back at SportsLine.

Why the Orioles can win

Baltimore is expected to send right-hander Charlie Morton (5-8, 5.58 ERA) to the mound. In 21 games, including 15 starts, he has logged 88.2 innings pitched, allowing 97 hits, 55 earned runs, and 41 walks with 92 strikeouts. In a 3-1 win over the New York Mets on July 10, he received a no-decision. In that game, he pitched six innings, allowing four hits, one earned run, and three walks with four strikeouts.

Among the Orioles’ top hitters include first baseman Ryan O’Hearn. The former eighth-round pick of the Kansas City Royals in the 2014 MLB Draft is hitting .281 through 88 games this season. He has registered 14 doubles, 12 homers, 37 RBI and three stolen bases. In a 5-2 win over the Miami Marlins on July 11, he was 2-for-4 with a double and two RBI. See which team to back at SportsLine. 

How to make Orioles vs. Guardians picks

SportsLine’s model is leaning Under on the total, projecting 8.9 combined runs, and it says one side of the money line has all the value. You can head to SportsLine to see the model’s MLB picks. 

So who wins Orioles vs. Guardians, and which side of the money line has all the value? Visit SportsLine now to see which side you need to jump on, all from the model that has crushed its MLB picks, and find out.