9 Best Peptide Lip Treatments for a Smoother, Fuller Pout

When Hailey Bieber included the Peptide Lip Treatment as one of the debut offerings from her cosmetics label Rhode in June 2022, many underestimated not only its popularity, but also its efficacy. It was a year marked celebrity beauty launches, and a collective pessimism permeated the discourse. Few in the industry anticipated her “one of everything good” POV to resonate so strongly, especially one buoyed by a humble lip product.

Vogue‘s Favorite Peptide Lip Treatments

This is not to say that Rhode’s lip balm was the first to add peptides to its formula, but it surely was the one that popularized the trend—at a time when the ingredient was just joining the skin-care conversation. “Peptides are short chains of amino acids that are the building blocks of proteins like collagen and elastin, which helps our skin maintain firmness and elasticity,” board-certified dermatologist Dr. Azadeh Shirazi tells Vogue. “In skincare, peptides trick your skin into producing more of these supportive proteins. When used in lip products, peptides like palmitoyl tripeptide signal the skin to produce more collagen, leading to plumper, firmer, more hydrated lips over time.”

She goes on to explain that the skin on our lips is much thinner, more delicate, and more vulnerable to environmental stressors compared to the rest of our face; so, the gentleness of peptides makes them incredibly effective at improving fine lines, dryness, and volume loss. “Plus, they’re incredibly versatile as they hydrate, smooth, and subtly plump without causing irritation,” Dr. Shirazi.

That said, it’s no surprise that the whole “peptide lip treatment” trend has taken off the way it has—blending efficacy with modern, tasteful tints suited for no-makeup days or dressed up with a lip liner. “We’re living in a time where skincare meets glam,” celebrity makeup artist Lauren D’Amelio Ventre says. “Consumers are no longer choosing between beauty and function, they want both. These formulas are working overtime to support barrier health, smooth texture, and even stimulate collagen. But yes, there’s also a certain glassy, plush aesthetic that makes them totally addictive.”

Best Overall: Rhode Peptide Lip Tint

• Why We Love It: A certified cult-favorite, Rhode’s peptide lip tint delivers on both nourishment and tint. “I love how it delivers both immediate moisture and long-term lip-smoothing benefits without feeling sticky,” Dr. Shirazi says. “Lightweight but still healing,” boasts Ventre. “This formula nails the balance of hydration and shine, great for a nighttime treatment or layered under gloss.” Go for shade Ribbon for a sheer pink (like Ciarlo, above), Espresso for a rich, chocolatey brown, or new shade Lemontini for a shimmering gold.
• Key Ingredients: Shea butter, peptides, cupuacu, babassu
• Shades: 6

Best Satin-Finish: Ole Henriksen Pout Preserve Peptide Lip Treatment

Ole Henriksen

Pout Preserve Peptide Lip Treatment

• Why We Love It: “Packed with peptides and antioxidant-rich oils, I recommend this one for clients who need serious repair but don’t want to sacrifice that fresh, juicy lip look,” Ventre says. The focus here is restoring bounce to the lips for a more visible fullness by way of the peptides, while Kokum and mango seed butter create a satiny, buttery finish that restores lips’ moisture levels. A TikTok darling, don’t be surprised when you’re hooked on this formula.
• Key Ingredients: Peptides, Kokum and mango seed butter, cloudberry oil, acai sterols
• Shades: 6

Best Shine: Topicals Slick Salve Lip Balm

• Why We Love It: If you want an intensive treatment that’ll last for hours without fail, look no further than the Topicals Slick Salve. I keep one tube of its cocktail of peptides, ceramides, hyaluronic acid, and shea butter at my bedside and another in my purse for reapplication when needed, though its “cling technology,” (i.e. a blend of fixing polymers) makes the need for reapplying infrequent. Absorbing quickly into lips and non-sticky, Dr. Shirazi would recommend this “for those who have lip sensitivities or chapped lips because of the CBD and humectant properties.”
• Key Ingredients: Peptides, ceramide blend, hyaluronic acid, shea butter,  castor seed oil, lysine, lanolin
• Shades: 3

Best Reparative: U Beauty The Plasma Lip Compound

• Why We Love It: U Beauty’s Lip Compound is a favorite of Dr. Shirazi’s “due to the stem cell technology [that] deeply nourishes while subtly firming without feeling heavy.” Its Siren Capsule Technology, in particular, works to optimize skin’s collagen for lip renewal, while a blend of peptides, ceramides, hyaluronic acid spheres, and plant extracts alleviate signs of dehydration. And with a whopping 16 shades to choose from, there’s a hue for any skin tone—or occasion.
• Key Ingredients: Peptides, ceramides, alpha hydroxy acid, poly-hydroxy acid, shea butter, salicylic acid, beeswax
• Shades: 16

Best Stick: Augustinus Bader x Sofia Coppola The Tinted Lip Balm

• Why We Love It: Sofia Coppola’s take on Augustinus Bader’s lip balm has become quite the Vogue editor favorite. Executive fashion director Libby Page is known to keep it in her bag, while beauty shopping writer Concetta Ciarlo considers it a daily work staple. “Initially, I was pulled in by the sheer fact of the Sofia Coppola collab—yes, I did judge a book by its cover,” she muses. “But getting down to business, this formula is so hydrating—like a buttery shea balm, plus the tints are rosy, subtle and gorg.”
• Key Ingredients: TFC8 (a proprietary blend of vitamins, lipids, peptides), lip-plumping complex, castor seed oil, shea butter, glycerin, peptides, antioxidants including vitamin E
• Shades: 3

Best Plumping: La Mer The Lip Volumizer

• Why We Love It: La Mer’s The Lip Volumizer surprised me. “This is more of a treatment than a gloss or balm—it smooths, hydrates, and plumps over time, leaving a silky, balm-like finish,” pro makeup artist Ash K. Holm previously told Vogue. I anticipated its nourishing properties (via the Miracle Broth formula La Mer is known for), apt to give my lips the TLC they desire, but I didn’t expect it to deliver aesthetically, too. The shades are subtle—great for the minimalist or subtle plumping. “I use this for VIP clients before a red carpet, hydrating, firming, and delivers that ‘lit-from-within’ lip glow,” Ventre adds.
• Key Ingredients: Miracle Broth, hyaluronic acid, coconut oil
• Shades: 5

Best Exfoliating: Eadem Le Couchou Peptide Lip Balm

EADEM

Le Chouchou Exfoliating + Softening Peptide Lip Balm

• Why We Love It: What sets Eadem’s lip balm apart from others on this list is that it gently exfoliates the list—a benefit that makes Ventre dub it a smart multitasker, ideal to create “a smooth canvas without harsh scrubs.” The idea here is to offer three properties in one formula—exfoliating, moisturizing, and lip color—via six modern shades that impart a sheen finish. Vegan, cruelty-free, and dermatologist-tested, what’s not to love?
• Key Ingredients: Hibiscus enzymes, lactic acid, pyruvic acid, Brazilian acai butter, African mongongo butter, moringa oil, hexapeptide, Spreadit polymer technology
• Shades: 6

Best Buttery: Dior Addict Lip Butter Glow

• Why We Love It: The dangling silver Dior charm isn’t the only reason to covet its Addict Lip Glow Butter. Per Ventre, “this one brings the pigment and peptide-powered hydration in one swipe.” The formula draws upon not only peptides, but ceramides and squalane—whipped into a buttery texture crafted for lasting moisture.
• Key Ingredients: Peptides, ceramides, squalane
• Shades: 5

Best Mask-Like: Farmacy Lip Smoothie

• Why We Love It: Of all the treatments on this list, Farmacy’s Lip Smoothie is the closest you’ll get to a lip mask. Powered by peptides, vitamin C, and fruit extracts depending on the flavor, this has all the makings for a reparative and replenishing formula. Both our experts cite it as great for daily wear—enveloping your pout in a high-shine glossy finish that’ll leave lips glistening for hours on end.
• Key Ingredients: Peptides, vitamin C
• Shades: 5